![]() Meta-analysis showed that higher plasma levels of VWF antigen, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 antigen (PAI-1) antigen, and soluble thrombomodulin (sTM) were associated with composite poor outcome in COVID-19 patients (, p < 0.001 I 2:80.4%],, p = 0.003 I 2:6.4%],, p = 0.025 I 2:7.9%], and, p = 0.015 I 2:23.6%], respectively). The estimated pooled means for von Willebrand Factor (VWF) antigen levels in COVID-19 patients was higher compared to healthy control (306.42, p < 0.001 I 2:86%), with the highest VWF antigen levels was found in deceased COVID-19 patients (448.57, p < 0.001 I 2:0%). To better understand the prognostic values of endothelial dysfunction in COVID-19-associated coagulopathy, we conducted a systematic review and meta-analysis to assess biomarkers of endothelial cells in patients with COVID-19.Ī literature search was conducted on online databases for observational studies evaluating biomarkers of endothelial dysfunction and composite poor outcomes in COVID-19 patients.Ī total of 1187 patients from 17 studies were included in this analysis. Several studies have reported that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect endothelial cells, and endothelial dysfunction is often found in severe cases of coronavirus disease 2019 (COVID-19). ![]()
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